For individuals struggling with treatment-resistant depression (TRD), finding an effective treatment can feel like an insurmountable challenge. Traditional antidepressants, such as SSRIs, often fail to deliver relief for those with TRD, leaving many to search for alternative solutions.
Spravato® (esketamine), a breakthrough nasal spray medication, has emerged as a promising option for those with TRD. By offering rapid symptom relief, it provides hope for individuals who have tried multiple medications without success. However, like any treatment, understanding the potential spravato side effects is essential to making informed decisions.
This guide will explore what Spravato® treatment is, how it works, and the common and rare spravato side effects you may encounter during treatment.
What Is Spravato®?
Spravato®, the brand name for esketamine, is a prescription medication approved by the FDA to treat adults with treatment-resistant depression and major depressive disorder (MDD) accompanied by suicidal thoughts. Unlike traditional antidepressants, Spravato® works as an NMDA receptor antagonist, targeting glutamate, a key neurotransmitter involved in mood regulation.
Administered as a nasal spray, Spravato® is not designed to be a standalone treatment. Instead, it is used alongside other approaches, such as therapy and oral antidepressants, as part of a comprehensive care plan tailored to the individual.
By targeting glutamate receptors, Spravato® promotes the regrowth of synaptic connections in the brain. This process improves communication between brain cells, leading to enhanced mood regulation and symptom relief for individuals who have not responded to traditional treatments.
The treatment process begins with an initial phase of twice-weekly doses for the first four weeks. Following this, patients move into a maintenance phase, receiving doses once every one to two weeks, depending on their specific needs and progress.
Due to its unique mechanism and potential risks, Spravato® is only available through REMS-certified facilities. At these facilities, trained professionals supervise the administration of the medication to ensure safety and effectiveness throughout the treatment process.
Common Spravato Side Effects
While Spravato® can be a game-changer for managing TRD, it’s important to be aware of potential spravato side effects. The most commonly reported spravato side effects include:
Physical Symptoms:
- Nausea
- Dizziness
- Increased blood pressure
- Headache
Sensory or Emotional Symptoms:
- Feeling disconnected from reality (dissociation)
- Feeling sleepy or sedated
These spravato side effects are typically mild and short-lived, often resolving within hours or by the end of the day. However, it’s crucial to remain at the treatment center for at least two hours after each dose, allowing healthcare providers to monitor for any adverse reactions.
In rare cases, more serious side effects such as difficulty breathing, vision changes, or chest pain may occur. These require immediate medical attention. Discuss any concerns with your treatment team to ensure a safe and comfortable experience with Spravato®.
Serious or Rare Side Effects
While most spravato side effects are mild and short-lived, there are some rare but serious spravato side effects to be aware of:
Respiratory Depression
In rare cases, Spravato® may cause hypoventilation, where breathing slows significantly. This can lead to complications such as respiratory failure or cardiac arrest. During treatment, healthcare providers monitor your oxygen levels to ensure safety.
Significant Blood Pressure Changes
Spravato® can temporarily elevate blood pressure, which typically peaks 40 minutes after administration and subsides within four hours. However, in rare cases, it can lead to dangerously high blood pressure, increasing the risk of chest pain, vision changes, or seizures.
Suicidal Thoughts or Actions
While Spravato® itself is not directly linked to increased suicidal thoughts, the antidepressant medications required alongside it can heighten these risks, particularly in individuals under 24 years old. Immediate medical attention is needed if sudden changes in mood, thoughts of self-harm, or worsening depression occur.
By remaining under observation at a REMS-certified facility, the risks of serious spravato side effects are minimized, ensuring that any complications are promptly addressed.
Managing and Mitigating Side Effects
Although spravato side effects are common, there are practical steps you can take to manage and minimize discomfort:
Diet and Hydration
Avoid eating two hours before your treatment session to reduce the likelihood of nausea. Stay hydrated, but refrain from drinking fluids 30 minutes before your dose.
Rest and Preparation
Plan for post-treatment downtime. The sedation or fatigue that follows a session makes it unsafe to drive or operate machinery, so arrange transportation in advance.
Symptom Tracking
Keep a journal to monitor spravato side effects. Document when they start, how long they last, and what triggers may be involved. This information helps your treatment team make necessary adjustments.
Medical Interventions
Over-the-counter remedies or prescribed medications can alleviate certain spravato side effects, such as anti-nausea drugs for dizziness or herbal options like ginger tea and peppermint to address nausea.
Working closely with your treatment team ensures that these strategies are tailored to your individual needs, making your experience with Spravato® more manageable.
Working with Your Treatment Team
Collaboration with your healthcare providers is key to successfully managing Spravato® treatment. Here’s how they can support you:
Monitoring Your Progress
Regular check-ins help assess how well the treatment is working and ensure your safety. Your providers will track your response and adjust dosages if necessary.
Comprehensive Treatment Planning
Spravato® works best as part of a broader care plan that includes therapy and other medications. Your treatment team will tailor this plan to address your unique symptoms and goals.
Safety Measures
REMS-certified providers are specially trained to administer Spravato® and manage its risks. By choosing a facility like Southern Live Oak Wellness, you gain access to professionals who prioritize your safety and well-being.
Clear communication with your team is crucial. Share any spravato side effects, changes in mood, or concerns during your treatment journey to ensure the best possible outcomes.
Long-Term Considerations and Safety
Spravato® offers rapid relief for treatment-resistant depression, but long-term considerations are vital for ensuring its safe and effective use.
Cognitive Impairment Risks
Although cognitive impairment has been linked to long-term ketamine misuse, such risks have not been observed with Spravato® at prescribed doses. Still, cognition is carefully monitored during treatment, and patients are advised to avoid activities like driving on treatment days.
Potential for Misuse
As a ketamine derivative, Spravato® carries a low risk of misuse. However, strict administration protocols through the FDA’s Risk Evaluation and Mitigation Strategy (REMS) program limit access and frequency to prevent dependency.
Suicidal Risk Management
While Spravato® itself is not directly tied to increased suicidal thoughts, the accompanying antidepressants can elevate risks in younger patients. Maintaining open communication with your healthcare provider and closely monitoring mood changes is crucial.
By adhering to prescribed guidelines and maintaining close oversight with a REMS-certified provider, you can safely integrate Spravato® into your treatment plan.
Is Spravato® Right for You?
Deciding whether Spravato® is the right treatment involves evaluating your unique needs and circumstances:
Consider Your Medical History
Conditions like high blood pressure, heart disease, or a history of substance misuse may affect your suitability for Spravato®.
Previous Treatment Experiences
If traditional antidepressants have been ineffective, Spravato® could offer the breakthrough relief you’ve been seeking.
Collaboration with Providers
Your treatment team will assess whether Spravato® aligns with your overall mental health goals and develop a comprehensive plan tailored to your needs.
Spravato® is not a one-size-fits-all solution, but it can be a transformative part of a broader treatment approach for those struggling with treatment-resistant depression.
Start Your Spravato® Treatment Today
Spravato® is a groundbreaking option for individuals with treatment-resistant depression, offering rapid symptom relief where traditional treatments fall short. While most spravato side effects are mild and short-lived, understanding potential risks and working closely with a REMS-certified provider ensures safety and effectiveness throughout your treatment journey.
If you or a loved one are considering Spravato® as a treatment option, Southern Live Oak Wellness provides compassionate, expert care in a safe and supportive environment. Our team is here to guide you through every step of your mental health journey, offering tailored solutions that empower long-term healing.
Take the first step toward relief today. Contact Southern Live Oak Wellness to learn more about Spravato® and start your path to recovery.