Spravato is a prescription drug used in conjunction with antidepressants to treat treatment-resistant depression and/or symptoms associated with major depressive disorder. Those who have used Spravato have seen results in just four weeks, and after sixteen weeks, many stopped therapy completely. Spravato is a self- administered nasal spray taken 1-2 times per week depending on your start date. It has been tested for long-term safety and poses very few threats to its users. Spravato targets the N-methyl-D-aspartate (NMDA) receptor, opposed to antidepressants, which aim to raise levels of serotonin and dopamine.